In summary, LRP1–SNRNP25 expression can increase the protein expression and activity levels of pJNK, 37LRP, and MMP2, and LRP1–SNRNP25 fusion protein forms a protein complex with pJNK and 37LRP, thus activates MMP2 and plays important role in promoting the invasion and migration of osteosarcoma cells (Fig. 7). The gene discussed is LRP1; the disease is osteosarcoma.