LRP1 and osteosarcoma: In summary, this study further confirmed the existence and biogenesis mechanism of the previously discovered fusion gene LRP1–SNRNP25 at the DNA level and revealed the mechanism by which LRP1–SNRNP25 promotes the invasion and metastasis of osteosarcoma cells through the pJNK/37LRP/MMP2 signaling pathway in vivo and in vitro.