However, in osteosarcoma, only two fusion genes have been reported: Debelenko et al. reported the discovery of a single EWSR1–CREB3L1 fusion gene in a case of small-cell osteosarcoma, and Kang et al. reported Rab22a–NeoF1 [12–14]. The gene discussed is CREB3L1; the disease is osteosarcoma.