The absence of PINK1 inhibits PINK1-dependent mitophagy, and although cells may clear mitochondria through other pathways, the efficiency of their elimination is reduced, resulting in the accumulation of damaged mitochondria, iron, and synuclein alpha (SNCA) or even ferroptosis in the substantia nigra of PD patients [176, 177]. The gene discussed is PINK1; the disease is Parkinson disease.