Drugs such as itaconate derivative 4-octyl itaconate and tumor suppressor p53 disrupt the balance of the tumor microenvironment by interfering with the Warburg effect, promoting cancer cells to shift from aerobic glycolysis to OXPHOS, and promoting the establishment of high copper environments that are conducive to cancer cell growth and cause damage to cancer cells through cuproptosis or other forms of oxidative stress-induced death [196, 197]. Here, TP53 is linked to cancer.