Lower NEEV miR-93 expressions were associated with higher serum IL-1ra (r = −0.39, p = 0.013; Fig. 3A), IL-6 (r = −0.40, p = 0.012; Fig. 3B), TNF (r = −0.37, p = 0.018; Fig. 3C), and leptin (r = −0.34, p = 0.035; Fig. 3D) concentrations in MDD participants but no such relationship was observed in HCs (IL-1ra, r = 0.11, p = 0.528; IL-6, r = 0.01, p = 0.942; TNF, r = 0.13, p = 0.457; leptin r = 0.00, p = 0.996). Here, LEP is linked to major depressive disorder.