At present, studies on the FBXO11 gene mainly focus on various tumors, such as renal cell carcinoma, gastric cancer, human B-cell lymphoma, etc.33, 34, 35 Other diseases related to FBXO11 gene variation include chronic otitis media, vitiligo, etc. For the mechanism of OA, FBXO11 has not been deeply studied in this respect. This evidence concerns the gene FBXO11 and renal cell carcinoma.