INS and overnutrition: When there is prolonged overnutrition, the white adipose tissue (WAT) becomes progressively inflamed and dysfunctional.2, 3, 4 This maladaptive state of the WAT can cause surplus lipid release and deposition within the liver and other tissues,5 potentiating insufficient insulin secretion from pancreatic β-islet cells, insulin resistance and development of T2DM.3