The commonly down-regulated CYP-derived diols and up-regulated 12,13-EpOME:DiHOME in obese WAT and plasma were further analysed in relation to (i) their association with WAT phenotypes (Fig. 1, Fig. 2, Fig. 3), (ii) their cross-tissue correlation (i.e. WAT vs. plasma), (iii) their relative predictive value of T2DM. This evidence concerns the gene PPIG and type 2 diabetes mellitus.