PPIG and obesity due to melanocortin 4 receptor deficiency: Strikingly, the most significant changes were observed within the 8 CYP-derived metabolites decreasing with obesity (10,11-DiHDPA, 5,6-DHET, 8,9-DHET, 11,12-DHET, 14,15-DHET, 12,13-EpOME, 9,10-DiHOME, and 12,13-DiHOME), especially in AA, LA and DHA-derived fatty acid diols (Fig. 4b and c).