Oxylipins were studied in association with obesity/T2DM or MASLD/Metabolic dysfunction-associated steatohepatitis (MASH) in human patients.39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57 COX and LOX-derived oxylipins were generally found to increase during metabolic syndrome,41,46,48,54, 55, 56, 57 though the association of CYP-derived epoxides and their corresponding diols remains unclear. This evidence concerns the gene PPIG and obesity due to melanocortin 4 receptor deficiency.