In summary, our WAT phenotyping shows that adipocyte hypertrophy (i.e. adipocyte size), type I collagen, PPARγ/CEBPα reduction (hyperplasia) are indicative of homeostatic remodelling during obesity, while macrophage numbers, type VI collagen are cellular and histological markers of progression toward T2DM. The gene discussed is CEBPA; the disease is obesity due to melanocortin 4 receptor deficiency.