To underscore the biological significance of CARM1-mediated GATAD2A/2B methylation and transcriptional events, high expression of CARM1 and NuRD is observed in clinical breast cancer samples, and knockdown of CARM1 and NuRD significantly attenuates breast cancer cell growth in vitro and tumorigenesis in vivo. Here, GATAD2A is linked to breast carcinoma.