CARM1 is thought to contribute to cancer progression mainly through its coactivator activity targeting a plethora of transcription factors, such as p53, E2F1 and NFκB (29–31), and/or its methyltransferase activity directly targeting oncogenic proteins, such as BAF155, MED12, and PKM2 (17,18,20,23). The gene discussed is CARM1; the disease is cancer.