INS and type 2 diabetes mellitus: Additionally, KEGG enrichment analysis revealed significant associations between these 113 genes and PPAR signaling pathway, adipocytokine signaling pathway, regulation of adipocyte lipolysis, insulin resistance, type II diabetes, fat digestion and absorption, cAMP signaling pathway, insulin signaling pathway, and AGE-RAGE signaling pathway in diabetic complications (Fig. 3D).