Moreover, although Casp2−/− mice do not develop tumors spontaneously (Shalini et al., 2012), loss of Casp2 promotes tumorigenesis in many mouse models including Eμ-Myc lymphoma (Ho et al., 2009), c-Neu-driven mammary carcinoma (Parsons et al., 2013), and ATM−/− lymphoma (Puccini et al., 2013). This evidence concerns the gene CASP2 and lymphoma.