In addition to NR3C1, FK506 binding protein 5, encoded by the gene FKBP5, is a modulator of NR3C1 activity and the HPA stress response, further justifying the importance of focusing on both NR3C1 and FKBP5 methylation in relation to lifetime trauma exposure and PTSD symptoms. The gene discussed is FKBP5; the disease is post-traumatic stress disorder.