Prior studies have looked at the effects of either trauma exposure or PTSD on NR3C1 methylation, but with inconsistent findings across studies of the associated CpG sites within NR3C1 (Watkeys et al., 2018), suggesting distinct contributions of trauma exposure and trauma-related sequalae to NR3C1 methylation. This evidence concerns the gene NR3C1 and post-traumatic stress disorder.