As the *T allele of IFNG +874T/A provides a binding site for nuclear factor κB (NF-κB), thus up-regulating IFNγ expression [16], it is possible that this allele significantly contributes and paves the way to the symptomatic manifestation of COVID-19, as its frequency is higher in infected patients than in the general population. This evidence concerns the gene NFKB1 and COVID-19.