However, it is also plausible to suppose that after the development of symptoms, which is influenced by the IFNG +874T/A polymorphism, the disease outcome, in terms of severity, may be more strongly determined by other factors, like genetic ones that are still unknown or environmental and biological factors, like age, comorbidities, sex, nutritional status and access to the healthcare system, which are already highlighted as major factors in the severity of COVID-19 [25,26,32]. The gene discussed is IFNG; the disease is COVID-19.