In line with this, TLR3 expression is enhanced in the brains and spinal cords of individuals with chronic neuroinflammation, such as those with multiple sclerosis or Alzheimer’s disease [44,81,82], suggesting that these findings could potentially be applied to cellular RNAs encapsulated in EVs and their contributions to other chronic neurocognitive disorders. This evidence concerns the gene TLR3 and multiple sclerosis.