CXCL8 and lymphoma: Furthermore, Ren et al. (2004) showed in epithelial/NPC hybrid cell line NPC-KT that LMP1 induces IL-8 by activation of NF-κB via the NF-κB binding site in the IL-8 promoter [116], while Vockerodt et al. (2005) demonstrated that the LMP1-mediated expression of IP-10 in lymphoma cells is independent of inducers such as IFN-γ, IL-18 and TNF-α and its promoter activity can be regulated by NF-κB signalling along with the p38 pathway [117].