Consistent with the previous research into liver myeloid cells during HCV-induced hepatitis [27], our iMACs facing HCV-infected Huh7 cells upregulated a separate list of genes related to the S100 program (i.e., S100A4 and S100A9), genes with antimicrobial functions (i.e., MARCO and CD163 of the scavenger receptor family, and RNASE2), and genes encoding pro-inflammatory proteins (i.e., CHI3L1, with an additional functions of tissue remodeling, and CCL4) (Supplementary Figure S3b). Here, S100A4 is linked to hepatitis A virus infection.