Furthermore, Rebekah A. Reynolds et al. found that the hormone 20E plays a role in preparing mosquito innate immunity against bacteria and malaria parasites, partly due to the activation of cellular immune pathways, and possibly involves a series of humoral factors, such as antimicrobial peptide CEC3, CLIP serine proteases, and lysozymes, making mosquitoes more resistant to pathogen infection [13]. This evidence concerns the gene LYZ and malaria.