Importantly, the effect of SLFN14 on HIV-1 protein expression was observed in several cell types, including primary cells implicated in HIV-1 infection in vivo (CD4+ T cells and monocytes) and in SUP-T1 and HEK293T cells; and on HIV-1 transcripts generated by plasmid transfection or by viral infection. This evidence concerns the gene CD4 and HIV-1 infection.