Due to the frequency of the polymorphic allele for TREX1 rs3135941 (T/C) being slightly higher in the group with HIV-1, with a p value close to the significance value of the test, it is possible that the lack of association of the TREX1 rs3135941 (T/C) polymorphism with HIV-1 infection may be related to our sample size. The gene discussed is TREX1; the disease is HIV-1 infection.