Among the various polymorphisms located in the TREX1 gene, some stand out in HIV-1 infection; the TREX1 rs3135941 (T/C) polymorphism was related to faster progression of the infection [23], and the TREX1 rs3135945 (G/A) polymorphism was associated with susceptibility to virus infection [22]. This evidence concerns the gene TREX1 and viral infectious disease.