TREX1 and HIV-1 infection: However, in contrast, previous studies showed an association between the TREX1 rs3135941 polymorphism (T/C) and the speed of progression of HIV-1 infection as result of increased virus replication, indicating that the TREX1 rs3135941 polymorphism (T/C) may promote higher exonuclease activity, which would result in reduced IFN-I production [23,26].