The genotype and allele distributions of the TREX1 rs3135941 (T/C) and TREX1 rs3135945 (G/A) polymorphisms were not associated with HIV-1 infection, and there was no association between the polymorphisms and the TREX1 gene expression, IFN-α, and CD4+ T lymphocytes levels. Here, CD4 is linked to HIV-1 infection.