The DEGs involved in cytokine signaling were upregulated following infection with RHDV2 and included inflammatory cytokines such as IL1α, IL-6, and IL-8, and chemokines such as CCL2, CXCL9, and CXCL11, which were significantly upregulated compared with the non-infected rabbits. The gene discussed is CXCL11; the disease is infection.