According to a recent research study from Switzerland, the risk factors for active tuberculosis in PLWH mainly include a plasma HIV-RNA load ≥ 1000 copies/mL, CD4 counts < 500 cells/μL, positive LTBI test (TST or IGRA), BMI < 18.5 kg/m2, non-white ethnicity and individual origin from a high tuberculosis epidemic region [17]. This evidence concerns the gene CD4 and tuberculosis.