Our result that most mouse PYHIN proteins share the antiretroviral activity of human nuclear PYHIN proteins agrees with the previous finding that mouse PYHIN proteins were dispensable for the type I interferon (IFN) response to transfected DNA ligands, as well as infection with DNA and RNA viruses [22], but associated with reduced control of Friend MLV replication early after infection [23]. This evidence concerns the gene IFNA1 and infection.