USP18 inhibits the NF-κB-signaling-mediated regulation of T-cell proliferation and IL-2 production by catalyzing the deubiquitination of the TGFβ-activated kinase/TAK-binding protein (TAB1/TAK1) complex, which provides evidence for USP18’s regulation of T-cell-mediated autoimmunity [82]. This evidence concerns the gene USP18 and Autoimmunity.