USP18, a member of the ubiquitin-specific protease (UBP) family with a molecular mass of 43 kDa, was first identified in mice expressing acute myeloid leukemia 1 (AML1)-eight twenty-one (ETO) (AML1-ETO) and later confirmed in virus-infected porcine alveolar macrophages and IFN-I-treated human melanoma cell lines [79,80,81]. Here, RUNX1 is linked to melanoma.