Figure 1B shows, on the one hand, that infection with MVA-T7 results in induction of TBK1 phosphorylation and that pMGF505-2R expression results in a decrease of the MVA-T7-induced TBK1 phosphorylation. These data demonstrate that pMGF505-2R expression is able to inactivate a central step of the cGAS-STING signaling pathway, in agreement with the above-observed inhibition of IFN-β promoter activation (Figure 1A). Here, CGAS is linked to infection.