This trend was not affected by (i) serotype (Ogawa or Inaba), (ii) previous or recent exposure to cholera when immunoglobulins (IgA, IgM, and IgG) were investigated with IgM being the most circulating immunoglobulin in the population, and that (iii) vibriocidal antibodies were a little lower in persons living with HIV when compared to their counterparts. The gene discussed is CD40LG; the disease is vibrio infectious disease.