We overlaid our data with the following clonotypes specific for the most immunogenic melanoma antigens: TRP-2, gp100, alloreactive H-2b graft clonotypes in H-2d hosts (graft versus host disease, GVHD), influenza A, vesicular stomatitis virus (VSV), mouse cytomegalovirus (MCMV), and murine leukemia virus (MLV). The gene discussed is PMEL; the disease is melanoma.