↓ weight gain; ↓ hyperlipidemia (↓ TG and TC); anti-diabetic activity (↑ glucose tolerance, ↓ insulin resistance, and ↑ insulin sensitivity); ↓ oxidative stress on cardiac tissue (↓ MDA in serum and heart and ↑ SOD, CAT, and GSH/GSSG, ↓ lipid peroxidation); counteracted the repression of AMPK/Nrf2/ARE antioxidant signaling axis in cardiac tissue; ↓ hyperglycemia-associated metabolic cardiac inflammation (↓ activation of NF-κB signaling pathway and ↓ mRNA levels of Il-1β, Il-6, and TNF-α). Here, INS is linked to Hyperglycemia.