By diminishing the level of cyclin B1 and regulating the phosphorylation of protein kinase Chk1 and p21, the level of Bcl-2 was significantly reduced, and the BAX, cytoplasmic Cytochrome-C (Cyt c), Caspase-9 and Caspase-3 levels were increased to produce an anti-tumor effect [60]. Here, BCL2 is linked to neoplasm.