In addition, it increases the levels of intracellular reactive oxygen species (ROS), PKR-like endoplasmic reticulum kinase (PERK), C/Ebp-Homologous Protein (CHOP), recombinant activating transcription factor 4 (ATF4) and Caspase 12 in glioblastoma cells via the activation of the lethal endoplasmic reticulum stress response and mitochondrial dysfunction and through the activation of endoplasmic reticulum stress-related protein reflection [65]. Here, DDIT3 is linked to glioblastoma.