AKR1C3 and breast cancer: Several studies have demonstrated that the AKR1C3 enzyme is related to some steroid hormones due to regulation, such as AR (androgen), ER (estrogen), and PgR (progesterone) [3]; it is overexpressed in several hormone-related cancers and is correlated with tumor development and resistance to anthracyclines such as doxorubicin, one of the first choices in breast cancer treatment [4].