NFE2L2 and Ureteral obstruction: A recent study has shown that obacunone (10 and 40 mg/kg, intraperitoneal injection) can inhibit ferroptosis by activating the nuclear factor erythroid 2-related factor 2 (NRF2)/GPx4 signaling pathway, thereby improving renal interstitial fibrosis in unilateral ureteral obstruction model mice [45].