GPX4 and Hepatic fibrosis: In a CCl4-induced liver fibrosis model, obacunone (1.5, 3, and 6 mg/kg) decreased alanine aminotransferase/aspartate aminotransferase (ALT/AST) levels and reversed the pathological changes in the liver tissue, with reduced expression levels of epithelial-mesenchymal transition-related proteins (e.g., α-smooth muscle actin and connective tissue growth factor) and lipid oxidation factors and enhanced expression of glutathione peroxidase 4 Gene (GPx-4).