On the other hand, serum withdrawal, or treatment with substances that promote growth arrest and differentiation, like retinoic acid (RA), dexamethasone (Dex), cAMP, and 1, 25-dihydroxyvitamin D3 (VD), tend to favor the induced levels of TGF-βs 2 and 3 over that of TGF-β1 or even suppress TGF-β1 (in the case of RA and Dex) [65,68,69,70,71,72]. This evidence concerns the gene TGFB1 and rheumatoid arthritis.