The same was observed for the expression of NR1I2 and TRPV1, which were found to be upregulated in the CD ileum when compared to the colon in both inflamed (NR1I2: FR = 1.85, padj = 4.58 × 1020; TRPV1: FR = 1.53, padj = 1.6 × 1033) and non-inflamed samples (NR1I2: FR = 2.06, padj = 6.03 × 1050; TRPV1: FR = 1.88, padj = 4.87 × 1048), but not in HIs, leading us to assume that these differences may either reflect a specific effect of IBD, or be associated with their pathogenesis. Here, TRPV1 is linked to inflammatory bowel disease.