Interestingly, we found that FFAR4 is upregulated in the colon of both IBD patients and healthy individuals, and that the inflammation-related overexpression of this receptor in CD is restricted to the ileum; this could indicate that an abnormal upregulation of this gene in the ileum may be important for disease development, though experimental data are needed to support this hypothesis. Here, FFAR4 is linked to inflammatory bowel disease.