INS and diabetes mellitus: Acute administration (3 h) of Vox2 (Figure 3B) or prolonged administration (12 days) (Figure 3D) by oral gavage did not present an insulin-mimetic effect in diabetes-treated animals, as reported in other studies with vanadium complexes, such as bis-(maltolato)oxidoovanadium(IV) [25,56] (VO(malto)2), polyoxidometalates [57], and peroxidovanadium complexes [48,53].