GSDMD and acute respiratory distress syndrome: In addition, clinical studies have found that sepsis-induced ALI can also be significantly attenuated through the effects of specific protein molecules including phospholipase A2 type IIA (Pla2g2a)-epidermal growth factor receptor (EGFR) [49], estrogen-related receptor alpha (ERRα) [50,51], mucin 1 (MUC1) [52], microRNA 199a (miR-199a) [53,54], gasdermin D (GSDMD) [55,56], tyrosine kinase with immunoglobulin, and epidermal growth factor homology domains 2(Tie2) [57,58].