We found that TKTL1 and CD8+ T cells, CD4+ T cells, T cell CD4+ memory resting and dendritic cells are positively correlated in KIRC, but not in KIRP and KICH (Supplementary Figure S3), which suggested that the underlying mechanism of TKTL1 leading to a different prognosis pattern in three kidney cancer subtypes might be the recruitment and infiltration of TILs. This evidence concerns the gene CD4 and kidney cancer.