In the overview of genes involved with a protective effect that demonstrated a statistically significant difference between RA patients and healthy controls, we found ACE (chr17_61566031), PARK2 (chr6_161990516), ACE2 (chrX_15596143), IL-18 (chr11_112014152 and chr11_112020916), IL-18R1 (chr2_102984684 and chr2_103010912), IL-4R (chr16_27358098), IL-6 (chr7_22767433), IL-7R (chr5_35861152 and chr5_35876274), TRAF6 (chr11_36518824), IFNGR1 (chr6_137519780), IL-12RB1 (chr19_18171886), TEME50B (chr21_34804966), IL-13 (chr5_131995843), NR112 (chr3_119526349), and PTPN22 (chr1_114400590). This evidence concerns the gene IL18R1 and rheumatoid arthritis.