In addition to identifying metabolic pathways, we have identified the top 10 bacterial genes (accB, ftsB, glyQ, hldD, lpxC, lptD, mlaA, ppsA, ppc, and tamB) as bacterial key genes (bKGs) capable of facilitating secondary infection with SARS-CoV-2 through protein–protein interaction network analysis. The gene discussed is ACACB; the disease is infection.