Cluster 1 includes pathways such as pathways in cancer (Figure 5), cytoskeleton-associated protein 4 (CKAP4) signaling pathway map, lipid and atherosclerosis, malignant pleural mesothelioma, gastric cancer (Figure 6), PI3K-Akt signaling pathway (Figure 7), endocrine resistance, response to hormone, proteoglycans in cancer, hepatitis C and hepatocellular carcinoma, photodynamic therapy-induced NF-kB survival signaling. The gene discussed is PIK3CA; the disease is cancer.