One study has shown that RSV can help in the treatment of glioblastoma (malignant brain tumor) by activating the mTOR signaling pathway, increasing AMPK phosphorylation, affecting different cascades in the MAPK pathway and down-regulating the PI3K/Akt pathway, thus leading to higher apoptosis levels and lower proliferation of cancerous cells reducing tumor volume [57]. The gene discussed is AKT1; the disease is neoplasm.