AKT1 and cancer: In one explanation, RSV acts as a chemosensitizer that modifies many subcellular pathways (p38-MAPK, Akt/STAT3, IL-6/JAK, and other signaling pathways) altering angiogenesis, apoptosis, metastasis, and transcription factors (RSV inhibits the NF-kB and its promoted end-proteins) suppressing cancer plasticity [59,60].