SIRPA and cancer: The engineered EVs were further loaded with Indocyanine green (ICG) dye and/or the anti-cancer drug, dinitroazetidine derivative RRx-001 (RRx-001), resulting in ICG/EVs and RRx-001/EVs, respectively, or a combination of both (ICG-RRx-001/EVs), serving as a blocker for the CD47/Signal Regulatory Protein Alpha (SIRPα) axis.