The good preparation activity of LNM lies in its good stability after repeated freezing and thawing, and its (1) ability to activate the cGAS-STING pathway and CD8+ T cells and promote anti-tumor immune response; (2) ability to induce the production of relevant cytokines such as IFN-γ and IL-6; and (3) use as an immune activating agent but also as a delivery system. The gene discussed is CGAS; the disease is neoplasm.