In an orthotopic mammary fat pad (MFP) mouse model, MDA-MB-231 TNBC cells with stable ADAM8 knockdown formed small tumors, which failed to induce angiogenesis and grow beyond a palpable size, shed fewer circulating tumor cells (CTCs) into the bloodstream, and resulted in profoundly reduced metastasis compared to control ADAM8-expressing MDA-MB-231 cells [6,8]. Here, ADAM8 is linked to neoplasm.