Dyrk1B was found to be overexpressed in various solid tumors and cancer cell lines, acting as a G0/G1 checkpoint kinase [16,48], maintaining the quiescence of cancer cells [16,18] and their viability under normoxic or hypoxic conditions [18,49], and as a tumor survival factor [16,35,37,45,50,51], thus conferring chemoresistance in cancer cells [52]. Here, DYRK1B is linked to cancer.