Previous studies have demonstrated that Dyrk1B protein levels are elevated up to 10-fold in quiescent G0 cancer cells and that Dyrk1B acts by several mechanisms to block cell proliferation and increase the expression of the antioxidant genes SOD2 and SOD3 resulting in reduced reactive oxygen species (ROS) levels and increased cell viability [58,71]. This evidence concerns the gene SOD3 and cancer.