The serum levels of albumin and urinary levels of creatinine were significantly increased, but serum creatinine levels and urinary levels of 8-OHdG, KIM-1, nephrin, and NGAL were significantly decreased in the STZ-T1DM + PHLTM rats compared to the STZ-T1DM rats (Table 2). This evidence concerns the gene NPHS1 and type 1 diabetes mellitus.