Based on these discussions, Li’s group [44] designed a composite therapeutic platform (MNP@BQR@ANG-EXO-siGPX4) based on the exosome-conjugated magnetic nanoparticles for brain-targeted co-delivery of GPX4-siRNA (siGPX4) and DHODH inhibitor (BQR) for GBM therapy. The gene discussed is DHODH; the disease is glioblastoma.