The mRNA molecules encode IRF5 and IKKβ, which imprint TAMs with a potent proinflammatory and anti-tumor M1 phenotype, and were complexed with a positively charged polymer cationic poly(β-amino ester) (PbAE) and then functionalized with a macrophage-targeting ligand Di-mannose to form the nanoparticles (IRF/IKKβ NP). Here, IKBKB is linked to neoplasm.