The anti-insulin-resistant effects of ethyl acetate (EE) and butanol (BE) extracts prepared from the aqueous extract were assessed on the palmitate-induced insulin resistance model of H4IIE (rat hepatoma cell line), C2C12 (immortalized mouse myoblast cell line), and 3T3L1 (murine adipocytes) cells using several metabolic parameters. The gene discussed is INS; the disease is hepatocellular carcinoma.