PCK2 and hepatocellular carcinoma: According to the study by Palatini Jackson et al. (2017), the three di-O-caffeoylquinic acids extracted from chicory suppressed hepatic glucose production in H4IIE rat hepatoma cells by reducing the expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes that regulate hepatic gluconeogenesis [416].