Likewise, IL-1β plays a critical role in physiological and pathological metabolism modulation (energy homeostasis), including insulin action and secretion, β-cell apoptosis, lipid metabolism, and food intake, by regulating the immune system and the neuronal and endocrine systems’ interface and, hence, in metabolic disorders, such as T2DM, MetS, and obesity [13,22,23,24,25,26]. The gene discussed is IL1B; the disease is metabolic disease.