Several studies have shown that PNPLA3 overexpression induces hepatic steatosis through the carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein 1c (SREBP1c), and its silencing prevents the development of hepatic fat storage and inflammation, thereby effectively preventing the development of NAFLD [12,13,14]. Here, SREBF1 is linked to Hepatic steatosis.