A considerable body of evidence suggests that many neurological and psychiatric disorders are accompanied by disorders of IMs, like interleukin (IL)-1b, IL-2, IL-6, interferon (IFN), tumor necrosis factor a (TNF a), the soluble IL-6 receptor (sIL-6R), and the IL-1 receptor antagonist (IL-1RA). Here, IL1B is linked to psychiatric disorder.