Many neurological and psychiatric disorders are associated with the impaired transport of fatty acids, including AD [244,245], stroke [246,247], motor neuron disease [248,249,250] (emerging links between lipid droplets and motor neuron diseases; axis regulates lipid metabolism under glucose starvation-induced nutrient stress; Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III), Huntington’s disease [251], Parkinson’s disease [252], etc. Here, SPAST is linked to stroke disorder.