These disorders include DD [135,136,137,138,139,140], ALS [141], AD [142,143,144], HE [145,146], etc. It has been suggested that pro-inflammatory cytokines can induce stress-induced neuroendocrine and central neurotransmitter changes similar to those in patients with depression [147], and IFN-a immunotherapy has been shown to induce depression [148,149]. This evidence concerns the gene IFNA1 and depressive symptom measurement.