MAPT and early-onset autosomal dominant Alzheimer disease: These impairments include AD [209,210,211], Lewy body disorder (LBD) [212,213], PD [206,214,215], etc. Impaired cortical cholinergic neurotransmission may also contribute to b-amyloid plaque pathology in Alzheimer’s disease and increased phosphorylation of tau, the major component of neurofibrillary tangles [216].