GAST and gastroesophageal reflux disease: Heat-killed LJ88 elicited anti-Helicobacter pylori activity both in vitro and in vivo [16], inhibited the increase in the number of gastrin-positive cells in the stomach induced by anti-Helicobacter pylori triple therapy including PPI in germ-free mice [17], and improved GERD-related symptoms in healthy adults in a pilot clinical study [18].