From our results, we could expect that luteolin, myricetin, and kaempferol, activating LXRα, might regulate lipid balance and reduce the inflammatory response mediated by COX-2, inducible NOS, TLR, NF-kB, and the phosphoinositide-3-kinase cascade involved in NASH. This evidence concerns the gene NR1H3 and metabolic dysfunction-associated steatohepatitis.