PPARA and metabolic dysfunction-associated steatohepatitis: Thus, PPARα has pivotal role in preventing the accumulation of lipids in the liver and the progression to NASH due to the synergistic effects of all activities responsible for control of the energetic homeostasis, together with its anti-hyphenation properties [45,54,55].The structure of PPARα is characterized by five domains: activation function 1 (AF1) domains A and B, the DNA binding domain (DBD), the ligand binding domain (LBD), and the hinge region.