And experimental studies at the animal-level have found several clues linking phospholipid metabolism to insulin resistance through the knockout of phospholipid synthesis enzymes, like phosphatidylethanolamine N-methyltransferase (PEMT) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) [9,10,11,12]. The gene discussed is PEMT; the disease is Insulin resistance.