TNFSF10 and colorectal cancer: In colorectal cancer cells, KEM has additionally been found to increase the level of the cell membrane-bound FAS ligand, which increases sensitivity to the pro-apoptotic effect of anti-TRAIL antibodies in the human chronic myeloid leukemia cell line, thus sensitizing them to TRAIL, which may indicate the induction of apoptosis through the activation of death receptors on the cell surface [30,77].