Additionally, Sabarwal et al. found that FIS caused an increase in total p53 in gastric cancer cells and is activated by phosphorylation at the S15 position, indicating the likelihood of its involvement in DNA damage [61].Subsequent studies involving gastric cancer cells with FIS showed a reduction in ERK activation 1/2 in a concentration-dependent manner, suggesting the involvement of another pathway in the initiation of apoptosis [62]. This evidence concerns the gene TP53 and gastric cancer.