CASP3 and neoplasm: The results indicate that ISO treatment significantly increased the expression of cleaved PARP, p53, cleaved caspase 9, BAX, cleaved caspase 3, and p27, while reducing the expression of BCL-2, N-cadherin, Slug, CDK1, p-PI3KP85α/γ/β, and p-AKT1 in the tumor tissues.